Genes and Environment

Formation of the toxic furan metabolite 2-butene-1,4-dial through hemin-induced degradation of 2,4-alkadienals in fried foods

Hiroshi Kasai, Kazuaki Kawai & Koichi Fujisawa 

BDA is efficiently generated from ADE in the presence of hemin under gastric conditions, and BDA-derived CPL can also form under physiological conditions through the interaction of ADE, hemin, Cys, and Lys. Additionally, a notable propensity for high BDA-dC adduct formation with hemin under acidic conditions was observed, consistent with the results of CPL assay and BDA–2,4-dinitrophenylhydrazone analysis.

Read this article: Volume 47, Article number: 8 (2025)

Role of TDP2 in the repair of DNA damage induced by the radiomimetic drug Bleomycin

Naoto Shimizu, Kazuki Izawa, Mubasshir Washif, Ryosuke Morozumi, Kouji Hirota & Masataka Tsuda

The contribution of the TDP-related pathway to DSB repair significantly differed between IR and radiomimetic drugs. The discovery of this novel TDP2-dependent repair of DSBs resulting from radiomimetic drug exposure indicates that TDP1 and TDP2 inhibition in combination with radiomimetic drugs represents a strategy for cancer treatment.

Read this article: Volume 47, Article number: 7 (2025)

• Article Collection of Papers Related to Oxidatively Damaged Bases Dedicated to Susumu Nishimura
• Research on Genes and Environment by the Malaysian Society of Toxicology 
• Lessons Learned from Japanese Association for Cancer Prevention and Future Opportunities
• Current topics in China for Environmental Mutagen Research
• G&E Best Paper Award collection
• Special Issue in memory of Takashi Sugimura 
• Asian Conference on Environmental Mutagens (ACEM2019)
• Article collection: Meeting Reports: collection of various meeting reports published in G&E
• Article collection: Genotoxicity Tests
• JEMS Open Symposia 2017&2018: “Challenges of Young Scientists”
• 10th Anniversary Special Issue
• JEMS Open Symposium 2015: “Life Style and Cancer”
• Asian Conference on Environmental Mutagens (ACEM2014)

Editor-in-Chief

Masami Yamada obtained her Ph.D. in bacterial genetics from Osaka University. Since 1990, she has been one of the leading researchers in environmental mutagen studies at the National Institute of Health Sciences in Tokyo, where she has developed numerous specialized bacterial strains based on standard Ames tester strains using genetic engineering techniques. These strains are widely utilized in environmental mutagen research and are actively distributed each year to research institutions across Asia, Europe, North and South America, and other regions. Since 2017, she has also shared her expertise by teaching Biology and Genetic Engineering at the National Defense Academy of Japan.

APC Discount for JEMS members
Members of Japanese Environmental Mutagen and Genome Society(JEMS)  are entitled to receive discount on Article Processing Charge. 

Free APC for researchers in Asia
We may offer a full APC waiver to the submissions from the countries where Asian Association of the Environmental Mutagen Societies (AAEMS)–partnering societies are located (excluding Japan). Those countries are Australia, China, India, Iran, South Korea, Philippines and Thailand. Please contact EIC (editor@j-ems.org) before submission.

To request APC discount
Authors are no longer requested to submit membership code during submission.
Please take following step to receive APC discount.
1) After manuscript submission, corresponding author informs EIC (editor@j-ems.org) of the manuscript number and membership number. 
2) When the manuscript was accepted for publication, author receives URL and asked to complete post-acceptance process. 
3) During post-acceptance process author requests APC discount by requsting 'Shared Support' on journal partner page.
4) EIC approves the request and discount is granted. 
5) Author pays discounted APC. 

*those authors who were offered full APC coverage by the editor (for invited/solicited papers), should select 'Prepay for invited papers' to receive full coverage. 

see also
-Changes in Submission Process (in Japanese)
-Post acceptance workflow process (Author Journey)