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Fig. 4 | Genes and Environment

Fig. 4

From: Role of hepatic cytochrome P450 enzymes in the detoxication of aristolochic acid I; effects on DNA adduct, mutation, and tumor formation

Fig. 4

Histopathological features of neoplastic changes in WT gpt and HRN gpt delta mice induced by AAI. a, the papilloma with vacuolated cytoplasm, irregular nuclei and numerous mitoses, mainly atypical forms was found in one WT gpt mouse (HE × 400). b, the papilloma penetrated through muscularis mucosae found in forestomach of one HRN gpt mouse(HE × 200). c, Squamouse cell carcinoma was found in one HRN gpt delta mouse which had penetrated through stomach to invade esophagus (HE × 100). d, Adenoma was found in one HRN gpt delta mouse without squamous cell carcinomas (HE × 200). e, a metastasis was present in the liver of one HRN gpt delta mouse in which squamouse cell carcinoma had invaded into esophagus (HE × 500)

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Genes and Environment

ISSN: 1880-7062

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