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Fig. 3 | Genes and Environment

Fig. 3

From: Progerin, the protein responsible for the Hutchinson-Gilford progeria syndrome, increases the unrepaired DNA damages following exposure to ionizing radiation

Fig. 3

Inhibition of DSB repair foci formation by transient expression of GFP-progerin in NHDFs. a GFP-progerin plasmids were transiently expressed in early passage of MJ90 cells by lipofection, and formation of 53BP1 foci was monitored 1 h after exposure to 1 Gy (peak stage of repair foci formation). Typical examples of cell nuclei which showed strong (left) or weak (right) expression GFP-progerin are shown. b 53BP1 repair foci are predominantly formed in nuclei which expressed low levels of progerin (1 Gy exposure and 1 h incubation). Cells are rank-ordered by intensity of green fluorescence

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Genes and Environment

ISSN: 1880-7062

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