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Fig. 3 | Genes and Environment

Fig. 3

From: Acid-specific formaldehyde donor is a potential, dual targeting cancer chemotherapeutic/chemo preventive drug for FANC/BRCA-mutant cancer

Fig. 3

Sensitivity of DT40 cells and DT40-derived FANC/BRCA-deficient cells to HMTA. (a) Effects of lactic acid (LA) on the pH of complete medium at 39.5 °C in CO2 incubator. (b-d) Survival curves of parental DT40 cells and DT40 mutant cells exposed to HMTA at physiological pH (b), in the presence of 8.4 mM LA (pH 6.6–7.1) (c), and, in the presence of 12.6 mM LA (pH 6.4–6.9) (d)

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Genes and Environment

ISSN: 1880-7062

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