Fig. 2

Cross-reactivity of cwp/pdr mutant reporter gene assay yeast strains expressing ERα, ERβ, PR, and AR against endogenous steroid hormones. (A-C) Responses to non-primary sex steroid hormones were examined: E2 for AR and PR (A), TS for ERα, ERβ, and PR (B), and PS for ERα, ERβ, and AR (C). (D-F) Responses to corticosteroids: CS (D), HC (E), and AS (F) for ERα, ERβ, PR, and AR. Responses of AR assay yeasts to E1 and E3 were also examined (G and H). The wild-type AR assay yeast was also used as a reference. Data represent the mean ± SD of triplicate experiments