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Fig. 3 | Genes and Environment

Fig. 3

From: The failure of two major formaldehyde catabolism enzymes (ADH5 and ALDH2) leads to partial synthetic lethality in C57BL/6 mice

Fig. 3

Hypothetical mechanism of possible human diseases caused by endogenous formaldehyde in individuals with the ALDH2*2 allele. GSH depletion occurs due to systemic or local oxidative/glycation stress, leading to the failure of the main formaldehyde detoxification pathway via ADH5. Under such conditions, individuals with the ALDH2*2 allele, which normally oxidizes formaldehyde at lower levels, accumulate intracellular formaldehyde. The increased endogenous formaldehyde may induce various human health problems

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Genes and Environment

ISSN: 1880-7062

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