Fig. 2
From: The importance of expert review to clarify ambiguous situations for (Q)SAR predictions under ICH M7
Performance statistics for (Q)SAR predictions, before and following expert review, against compounds provided ahead of the workshop expected to be yield ambiguous (Q)SAR predictions. BA = balanced accuracy (\( \frac{Sens+ Spec}{2} \)), Sens = sensitivity (\( \frac{TP}{TP+ FN} \)), Spec = specificity (\( \frac{TN}{TN+ FP} \)), PPV = positive predictive value (\( \frac{TP}{TP+ FP} \)), NPV = negative predictive value (\( \frac{TN}{TN+ FN} \)), Cov = coverage (\( \frac{TP+ FP+ TN+ FN}{TP+ FP+ TN+ FN+ Eq+ OD} \)). aConservative call made by combination of predictions from Derek Nexus and Sarah Nexus. bExpert call following review of predictions from Derek Nexus and Sarah Nexus