Fig. 7
From: Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides
Oxidation of vinyl chloride to 2-chlorooxirane (vinyl chloride epoxide), rearrangement to 2-chloroacetaldehyde, and reaction with DNA (and RNA). The enzymes epoxide hydrolase and alcohol dehydrogenase (plus NADH) were used to attenuate each of the products and ascertain which is the major one involved in binding [33, 34]