Fig. 1

(a) Single nucleotide variant (SNV) counts of samples grouped by wood dust exposure and histological subtype. Sample difference tested with Wilcoxon rank-sum test. (b) Sums of mutations in signatures SBS18 and SBS36 grouped by wood dust exposure and histological subtype. Sample difference tested with Wilcoxon rank-sum test. (c) Single base substitution signatures of wood dust-exposed and non-exposed tumors produced with the SigProfiler method, with hierarchical clustering utilizing cosine distance and average linkage method. Signature activities are scaled as proportion of contribution to each sample’s total mutation count. An unscaled image is presented in Additional file 2 (Fig. S1)