Genome-wide somatic mutation analysis of sinonasal adenocarcinoma with and without wood dust exposure

Genes and Environment

Table 2 Sample exposure status and CN variants assigned to CN signatures

Sample	Tobacco	Wood dust	Subtype	CN2	CN17
SNC142^{a, b}	NA	exposed	ITAC	22	0
SNC12	NA	exposed	ITAC	0	16
SNC78^a	NA	exposed	ITAC	19	0
SNC105	smoker	exposed	ITAC	19	0
SNC214^a	smoker	exposed	ITAC	13	11
SNC229	smoker	exposed	ITAC	17	23
SNC19^a	smoker	exposed	ITAC	9	0
SNC41	non-smoker	non-exposed	ITAC	0	1
SNC131^b	NA	exposed	non-ITAC	0	24
SNC176	non-smoker	exposed	non-ITAC	0	21
SNC233^b	smoker	exposed	non-ITAC	2	5
SNC48	NA	non-exposed	non-ITAC	0	3
SNC232^b	non-smoker	non-exposed	non-ITAC	5	6
SNC186^b	non-smoker	non-exposed	non-ITAC	9	14
SNC215^a	smoker	non-exposed	non-ITAC	0	32

Table sorted by subtype. SNC72 was used as a control sample in CN calling and thus is not present in the result table. ITAC = intestinal-type adenocarcinoma. Columns CN2 and CN17 contain the count of variants matching COSMIC signatures for tetraploidy and homologous recombination deficiency, respectively. ^a=sample positive for SBS8 in SigProfiler analysis. ^b=sample positive for ID6 in SigProfiler analysis

ISSN: 1880-7062