Genome-wide somatic mutation analysis of sinonasal adenocarcinoma with and without wood dust exposure

Genes and Environment

Table 3 Tobacco smoke exposure status and doublet base substitution count by DBS signature

Sample	Tobacco exposure	DBS2	DBS78B
SNC12	NA	10	0
SNC131^{a, b,c}	NA	288	0
SNC142^b	NA	49	86
SNC78^{b, c}	NA	140	0
SNC48^b	NA	0	15
SNC176	non-smoker	0	6
SNC186	non-smoker	0	32
SNC232	non-smoker	2	0
SNC41	non-smoker	1	7
SNC105	smoker	33	0
SNC19	smoker	34	0
SNC214^b	smoker	196	0
SNC229	smoker	5	66
SNC233	smoker	0	10
SNC215^c	smoker	0	24

SNC72 is missing from the DBS analysis as the sample did not contain any doublet mutations. DBS78B is a composite signature of DBS4, DBS6, DBS7, and DBS11. ^a=SBS4 activity called in sample by SigProfiler. ^b=SBS4 activity called in sample by HDP (Additional file 2: Fig. S2). ^c=ID3 called in sample by SigProfiler

ISSN: 1880-7062