Table 4 Comparison of TP53 mutation calls from Sanger sequencing and WGS.
Holmila et al. 2010 | WGS | |||||
|---|---|---|---|---|---|---|
sample | TP53 genotype | exons | change | TP53 genotype | exons | change |
SNC12 | mutated | 5*, 7 | Gly244Cys | Het(3/22) | 7 | Arg248Gln |
SNC19 | WT | - | - | WT | - | - |
SNC41 | mutated | 6*, 7* | - | WT | - | - |
SNC48 | WT | - | - | WT | - | - |
SNC72 | WT | - | - | Het(3/30) | 8 | Arg282Gln |
SNC78 | mutated | 7 | Arg249Gly | Het(7/15) | 7 | Gly244Asp |
SNC105 | WT | - | - | WT | - | - |
SNC131 | mutated | 5 | Asp184Ala | WT | - | - |
SNC142 | mutated | 5 | Tyr163Cys | Het(10/70), Het(25/55) | 5, 7 | Tyr163Cys, Asn235Ser |
SNC176 | WT | - | - | WT | - | - |
SNC186 | mutated | 7 | Cys242Gly | Het(13/26) | 7 | Cys242Phe |
SNC214 | mutated | 5 | Thr155Pro | Het(34/66) | 5 | Thr155Pro |
SNC215 | WT | - | - | WT | - | - |
SNC229 | mutated | 8* | - | WT | - | - |
SNC232 | mutated | 5*, 7 | Gly245Val | WT | - | - |
SNC233 | mutated | 5 | Cys135Tyr | Het(5/22) | 5 | Cys135Tyr |