Genes and Environment

Table 4 Chemical-gene interaction associated with lung neoplasms

From: Mapping the influence of hydrocarbons mixture on molecular mechanisms, involved in breast and lung neoplasms: in silico toxicogenomic data-mining

Substance	Carbon tetrachloride (CRN 56-23-5)			Vinyl chloride (CRN 75-01-4)			Dibenz(a, h)anthracene (CRN 53-70-3)			Benzo(b)fluoranthene (CRN 205-99-2)			Benzo(k)fluoranthene (CRN 207-08-9)			Chrysene (CRN 218-01-9)
Interaction	mRNA Expr	Protein		mRNA Expr	Protein		mRNA Expr	Protein		mRNA Expr	Protein		mRNA Expr	Protein		mRNA Expr	Protein
Interaction	mRNA Expr	Expr	Activity	mRNA Expr	Expr	Activity	mRNA Expr	Expr	Activity	mRNA Expr	Expr	Activity	mRNA Expr	Expr	Activity	mRNA Expr	Expr	Activity
BIRC5	↑	↑					↑			↑	↑		↑			↑
CCND1	↑↓	↑					↑			↑			↑			↑
CYP1B1	↑						↑	↑		↑			↑			↑	↑
DNMT3A			↑							↑
ESR1	↑↓										↑	↑		↓		↑
FOS	↑↓	↑	↑										↑			↑
GSTP1^*	↑	↑	↓				↓			↑			↑			↑
HMOX1	↑↓	↑↓	↑	↓	↓					↑			↑↓
HRAS	↑
IL1B	↑	↑	↑	↓						↑			↑
IL6	↑	↑	↑	↓						↑		↑				↑
JUN	↑	↑	↑										↑			↑
KRAS^**	↑↓
TFRC		↓											↑
TNF	↑	↑	↑	↑		↑										↑
TP53^***	↑↓			↓	↑						↑	↑↓			↑↓

Expr: Expression; ↑ - increase; ↓ - decrease; ↑↓ - can both increase and decrease; ^*GSTP1 polymorphism ↑ susceptibility to vinyl chloride (117); ^**Vinyl chloride (44–47) and benzo(b)fluoranthene (50–51) ↑ mutagenesis of KRAS gene; ^***Vinyl chloride ↑ mutagenesis TP53 gene (45–46). TP53 protein increased susceptibility to dibenz(a, h)anthracene (62). The references link can be found in Supplementary Table 2

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ISSN: 1880-7062

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