Mapping the influence of hydrocarbons mixture on molecular mechanisms, involved in breast and lung neoplasms: in silico toxicogenomic data-mining

Table 5 Chemical-gene interaction associated with breast and lung neoplasms^ŧ

Substance	2-Methyl-1,3-butadiene (CAS No. 78-79-5)			1,3-Butadiene (CAS No. 106-99-0)			Dichloromethane (CAS No. 75-09-2)			Tetrachlorodibenzodioxin (CAS No. 1746-01-6)			Benzo(a)pyrene (CAS No. 50-32-8)
Interaction	mRNA Expr	Protein		mRNA Expr	Protein		mRNA Expr	Protein		mRNA Expr	Protein		mRNA Expr	Protein
Interaction	mRNA Expr	Expr	Activity	mRNA Expr	Expr	Activity	mRNA Expr	Expr	Activity	mRNA Expr	Expr	Activity	mRNA Expr	Expr	Activity
BIRC5^*				↑						↑↓	↑		↑↓	↓
CCND1		↑								↑↓	↑↓		↑↓	↑↓
CYP1B1							↓			↑	↑	↑	↑↓	↑	↑
DNMT3A				↓						↑↓		↑	↑↓	↑
ESR1							↓			↑↓	↑↓	↑↓	↑↓	↓	↑
FOS				↓			↓			↑↓	↑↓	↑	↑↓	↑
GSTP1^**				↑						↑↓		↑	↑↓	↑	↑
HMOX1				↑			↑			↑↓	↑↓		↑	↑↓
HRAS^***										↑↓	↑		↑↓	↑
IL1B^****				↓						↑	↑		↑	↑	↑
IL6								↑		↑↓	↑↓	↑	↑	↑	↑
JUN							↑			↑↓	↑↓	↑	↑↓	↑	↑
KRAS^#										↑↓	↑		↑
TFRC				↑						↑↓	↑		↑↓
TNF								↑		↑	↑↓	↑	↑	↑	↑
TP53^###										↑↓	↓	↓	↑↓	↑↓	↑

Expr: Expression; ↑ - increase; ↓ - decrease; ↑↓ - can both increase and decrease; ^ŧ1,2-Dichloropropane (CAS No. 78-87-5) interacted with only one common gene, TNF. It ↑ the expression of TNF mRNA; ^*BaP ↑ methylation of BIRC5 3’UTR (53); ^**BaP ↓ methylation of GSTP1 promoter (53); ^***2-Methyl-1,3-butadiene (isoprene) and 1,3-butadiene ↑ mutagenesis of HRAS gene (1). BaP ↓ methylation of HRAS 5’UTR (53); ^****BaP ↓ methylation of IL1B 5’UTR (53). ^#Isoprene, 1,3-butadiene and BaP ↑ mutagenesis of KRAS gene (50–51,57–59); ^##BaP ↓ methylation of MIR222 gene promoter (53); ^###BaP ↑ phosphorylation of TP53 protein (54–56). The references link can be found in Supplementary Table 2.

ISSN: 1880-7062