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Table 1 Genotoxicity profiles and carcinogenicity data for DEHP

From: Confirmation of Di(2-ethylhexyl) phthalate-induced micronuclei by repeated dose liver micronucleus assay: focus on evaluation of liver micronucleus assay in young rats

Ames test

in vitro mammalian cell tests

in vivo genotoxicity tests

Rodent carcinogenicity

‒

[19]

‒

(MLA [19])

‒

(CA, CMT [19], UDS [20], TGR in liver [21])

 + 

[19]

  

‒ / + 

(CA [19])

‒ / + / E

(MN [19])

  
  1. CA chromosomal aberration test, MLA mouse lymphoma assay, CMT comet assay, MN peripheral blood/bone marrow micronucleus test, UDS unscheduled DNA synthesis test, TGR transgenic rodent gene mutation assay
  2. ‒: negative; + : positive; E: equivocal