Table 1 Summary of the gpt assay and mutation frequency of mouse DNA samples
From: Effect of sequencing platforms on the sensitivity of chemical mutation detection using Hawk-Seq™
Sample ID | Dose (mg/kg/day) | Mutant frequency (×10− 6) in gpt assay | Overall mutation frequency (×10− 6 bp) in Hawk-Seq™ analysis | |||
|---|---|---|---|---|---|---|
HiSeq* | NovaSeq | NextSeq | DNBSeq | |||
1001 | 0 (Olive oil) | 1.34 | 0.22 | 0.32 | 0.43 | 0.32 |
1002 | 0 (Olive oil) | 1.49 | 0.23 | 0.40 | 0.50 | 0.21 |
1201 | 150 | 13.26 | 0.75 | 0.85 | 0.95 | 0.81 |
1301 | 300 | 26.73 | 1.24 | 1.32 | 1.46 | 1.38 |