Table 2 Prediction performance with various ddE threshold for total dataset

Sensitivity (%)

93.0

90.6

88.2

85.9

83.7

79.1

74.1

64.5

57.6

Specificity (%)

30.9

36.7

43.0

49.4

55.9

62.6

69.1

72.6

76.5

Positive prediction value (%)

48.1

49.7

51.6

53.9

56.7

59.4

62.3

61.8

62.8

Negative prediction value (%)

86.6

85.1

84.1

83.5

83.3

81.3

79.5

74.8

72.3

Accuracy (%)

56.3

58.7

61.4

64.3

67.2

69.4

71.1

69.3

68.8

Balanced accuracy (%)

62.0

63.7

65.6

67.6

69.8

70.9

71.6

68.5

67.0

Mathews correlation coefficient

0.34

0.35

0.36

0.37

0.38

0.37

0.35

0.29

0.26

Positive likelihood ratio

1.35

1.43

1.55

1.70

1.90

2.11

2.40

2.35

2.45

Negative likelihood ratio

0.23

0.26

0.27

0.29

0.29

0.33

0.37

0.49

0.55

Coverage^a (%)

86.8