Table 1 Examined GTHCs, NGTHCs, NGTNHCs and intermediate GTHCs/NGTHCs in the present study

1

GTHCs

2-acetylaminofluorene

AAF

 + 

MN + , UDS + 

 + 

mgl, ski

NL

36

2

aflatoxin B1

AFB

 + 

UDS + 

 + 

-

1

36, 37, 38

3

2-nitrofluorene

2NF

 + 

UDS + 

 + 

kid, sto

2B

36, 39

4

N-nitrosodiethylamine

DEN

 + 

UDS + , DNA single strand scission + 

 + 

eso, kid, vsc

2A

36, 40, 41

5

N-nitrosomorpholine

NNM

 + 

UDS + 

 + 

kid, adr, thy, pit

2B

36, 41–43

6

NGTHCs

clofibrate

CLO

-

Pig-a -, UDS -, DSB -, MN + 

 + 

pan, smi, dermatofibrosarcoma, tes

3

36, 44–47

7

ethanol

ETH

-

comet -, DNA strand break + 

 + 

adr, pan, pit

1

36, 48, 49

8

fenofibrate

FEN

-

comet + (weak), ND (UDS, MN)

 + 

pan, tes

NL

50, 51

9

gemfibrozil

GEM

-

ND

 + 

adr, pan, tes

3

36, 52, 53

10

hexachlorobenzene

HEX

-

(Dominant lethal test -)

 + 

bile duct, kid

2B

36, 54

11

phenobarbital

PHE

-

MN -, comet -, Pig-a -

 + 

adr, nas

2B

36, 45, 55, 56

12

WY-14643

WY

-

UDS -

 + 

Leydig cell, pancreatic acinar cell

NL

57, 58

13

NGTNHCs

allyl alcohol

AA

-

ND

-

-

NL

36, 59

14

aspirin

ASP

-

ND

-

-

NL

36, 60

15

caffeine

CAF

-

ND

-

-

3

36, 61

16

chlorpheniramine

CPA

-

ND

-

-

NL

36, 62

17

chlorpropamide

CPP

-

ND

-

-

NL

36, 63

18

dexamethasone

DEX

-

ND

-

-

NL

36, 64

19

diazepam

DIA

-

ND

-

-

3

36, 65

20

indomethacin

IND

-

ND

-

-

NL

36, 66

21

phenylbutazone

PBZ

-

ND

-

-

3

36, 67

22

theophylline

THE

-

ND

-

-

3

36, 68, 69

23

tolbutamide

TOL

-

ND

-

-

NL

36, 70

24

intermediate

methapyrilene

MP

-

MN + , comet -, UDS -

 + 

-

NL

36, 55, 71, 72

25

(GTHCs/NGTHCs)

monocrotaline

MCT

-

MN + , DNA-DNA interstrand crosslinks + ,

 + 

-

2B

36, 73, 74

26

thioacetamide

TAA

-

comet + , γ-H2AX + , MN -

 + 

bile duct

2B

36, 75–77