Role of TDP2 in the repair of DNA damage induced by the radiomimetic drug Bleomycin

Genes and Environment

Table 1 Panel of cell lines used in this study

Genotype	Functions of the deleted gene(s)	References
TDP1^−/−	TDP-related repair	[36]
TDP2^−/−	TDP-related repair	[34, 36]
TDP2^E152Q/E152Q	TDP-related repair	[24]
TDP1^−/−/TDP2^−/−	TDP-related repair	[30, 37]
TDP1^−/−/TDP2^E152Q/E152Q	TDP-related repair	[24]
53BP1^−/−	DSB repair (NHEJ)	[38]
DNA-PKCS^−/−	DSB repair (NHEJ)	[39]
LIG4^−/−/−	DSB repair (NHEJ)	[39]
RAD54^−/−	DSB repair (HR)	[39]
RAD54^−/−/LIG4^−/−/−	DSB repair (HR/NHEJ)	[39]
XRCC1^−/−	BER	[40]
PARP1^−/−	BER	[37]
XPA^−/−	NER	[26]
SPRTN^−/−	DPC repair, TLS	[41]
RAD18^−/−	TLS	[28]
POLη^−/−	TLS	[26]
MLH1^−/−	MMR	[42]
MLH3^−/−	MMR	[42]
POLε^exo−/−	Proofreading of replicative polymerase	[28]

BER base excision repair; DPC DNA-protein crosslink; HR homologous recombination; MMR mismatch repair; NER nucleotide excision repair; NHEJ nonhomologous end joining; TDP tyrosyl-DNA phosphodiesterase; TLS translesion DNA synthesis

ISSN: 1880-7062