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  2. Progerin, the protein responsible for the Hutchinson-Gilford Progeria Syndrome (HGPS), is a partially deleted form of nuclear lamin A, and its expression has been suggested as a cause for dysfunctional nuclear...

    Authors: Asao Noda, Shuji Mishima, Yuko Hirai, Kanya Hamasaki, Reid D. Landes, Hiroshi Mitani, Kei Haga, Tohru Kiyono, Nori Nakamura and Yoshiaki Kodama
    Citation: Genes and Environment 2015 37:13
    Content type: Research article Published on:

  3. The 4th Asian Conference on Environmental Mutagens was held at CSIR Indian Institute of Chemical Biology, Kolkata, during December 10–12, 2014, in collaboration with All India Congress of Cytology and Genetics...

    Authors: Ashok K. Giri and Takashi Yagi
    Citation: Genes and Environment 2015 37:19
    Content type: Meeting report Published on:

  4. According to published information, it has not been determined whether the inhalation of cigarette smoke can induce chromosome aberrations and/or point mutations in mice, though cigarette smoke is clearly carc...

    Authors: Takanori Nakamura, Yumi Ishida, Kasumi Ainai, Shigeto Nakamura, Satoru Shirata, Kazuhiro Murayama, Shin-ichiro Kurimoto, Katsuyasu Saigo, Ryo Murashige, Shuji Tsuda and Yu F. Sasaki
    Citation: Genes and Environment 2015 37:17
    Content type: Research article Published on:

  6. Here we describe recent advances in our understanding of the natural history of the house mouse, Mus musculus, with a focus on the genetic characteristics of the home territories and how this relates to prehistor...

    Authors: Hitoshi Suzuki, Lyudmila V. Yakimenko, Daiki Usuda and Liubov V. Frisman
    Citation: Genes and Environment 2015 37:20
    Content type: Review Published on:

  7. In DNA, 8-oxo-7,8-dihydroguanine (GO, 8-hydroxyguanine) is one of the most pivotal oxidatively damaged bases and induces G:C → T:A transversion mutations. DNA polymerase λ preferentially inserts dCTP opposite GO ...

    Authors: Hiroyuki Kamiya, Masahiro Kurokawa, Tetsuaki Makino, Miwako Kobayashi and Ichiro Matsuoka
    Citation: Genes and Environment 2015 37:10
    Content type: Research article Published on:

  9. Biological studies in animals and epidemiological findings in humans clearly demonstrate that estrogens including 17β-estradiol (E2) are weak carcinogens via both genetic and epigenetic mechanisms. Carcinogene...

    Authors: Zhuhong Zhang, Haifang Li, Mugimane G. Manjanatha, Tao Chen and Nan Mei
    Citation: Genes and Environment 2015 37:16
    Content type: Research article Published on:

  10. The Public Symposium of the Japanese Environmental Mutagen Society (JEMS), entitled “Regulatory Science”, was held at the Shiba-Kyoritsu campus of Keio University, Tokyo, on May 24, 2014. The concept of regula...

    Authors: Hajime Kojima and Toshio Kasamatsu
    Citation: Genes and Environment 2015 37:12
    Content type: Meeting report Published on:

  11. Hepatic cytochrome P450s (CYPs) play an important role in the metabolism of plant carcinogen, aristolochic acid I (AAI). In the present study, we employed hepatic NADPH-cytochrome P450 reductase null (HRN) gpt de...

    Authors: Yang Luan, Guozhen Xing, Jin Ren and Jun Gu
    Citation: Genes and Environment 2015 37:11
    Content type: Research article Published on:

  13. To examine whether the mutagenic potential of lung exposure to air-borne environmental mutagens is age dependent, we administered 1 mg of benzo[a]pyrene intratracheally to 11- and 24-month old (middle-aged and...

    Authors: Yasunobu Aoki, Akiko H. Hashimoto, Yoshiki Sugawara, Kyoko Hiyoshi-Arai, Sataro Goto, Kenichi Masumura and Takehiko Nohmi
    Citation: Genes and Environment 2015 37:7
    Content type: Research article Published on:

  14. Asbestos-induced formation of mesothelioma has been attributed to phenotypic and morphological changes in cells caused by polyploidization and aneuploidization, and multiwalled carbon nanotubes (MWCNTs) are su...

    Authors: Manabu Yasui, Nagisa Kamoshita, Tetsuji Nishimura and Masamitsu Honma
    Citation: Genes and Environment 2015 37:6
    Content type: Short report Published on:

  15. Genes and Environment is now at the start of a new era of publication as an open access journal. I believe that open access publication marks a turning point that will make Genes and Environment unique in the Asi...

    Authors: Yasunobu Aoki
    Citation: Genes and Environment 2015 37:5
    Content type: Letter to the Editor Published on:

  17. This study determined the association of TLR4 Asp299Gly and Thr399Ile with uncomplicated and severe malaria among Nigerian children of similar ethnic background in Lagos. The association of these SNPs with hig...

    Authors: Bamidele Abiodun Iwalokun, Afolabi Oluwadun, Senapon Olusola Iwalokun and Philip Agomo
    Citation: Genes and Environment 2015 37:3
    Content type: Research article Published on:

  19. The Health and Environmental Sciences Institute (HESI) is a non-profit scientific research organization based in Washington, D.C., U.S.A. HESI was established in 1989 as a global branch of the International Li...

    Authors: Ayako Takei
    Citation: Genes and Environment 2015 37:1
    Content type: Review Published on:

Genes and Environment is an official journal of The Japanese Environmental Mutagen and Genome Society (JEMS).

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