Skip to main content

Articles

Page 5 of 7

  1. Frustrated phagocytosis occurs when an asbestos fiber > 10 μm in length is engulfed imperfectly by a macrophage, and it is believed to be associated with chromosomal instability. Few studies have focused on dy...

    Authors: Takenori Ishida, Nobutoshi Fujihara, Tomoki Nishimura, Hisakage Funabashi, Ryuichi Hirota, Takeshi Ikeda and Akio Kuroda
    Citation: Genes and Environment 2019 41:14
    Content type: Research Published on:

  2. The repeated-dose liver micronucleus (RDLMN) assay is an effective and important in vivo test for detecting genotoxic compounds, particularly for those that require metabolic activation to show genotoxicity. I...

    Authors: Shuichi Hamada, Miyuki Shigano, Satoru Kawakami, Maya Ueda, Hajime Sui, Katsuya Yamada, Soichiro Hagio, Ayaka Momonami, Akihisa Maeda, Yukari Terashima, Wakako Ohyama, Takeshi Morita and Makoto Hayashi
    Citation: Genes and Environment 2019 41:13
    Content type: Research Published on:

  3. The MucA’ and MucB proteins comprise the core of DNA polymerase RI which is a strong mutator utilized in mutagenicity assays such as the standard Ames test. A close relative DNA polymerase V, composed of the h...

    Authors: Petr GrĂşz, Kei-ichi Sugiyama, Masamitsu Honma and Takehiko Nohmi
    Citation: Genes and Environment 2019 41:10
    Content type: Research Published on:

  4. In the original publication of this article [1], the author pointed out the reference list mismatched citations in the main text. All citations and reference has been updated.

    Authors: Shizuyo Sutou
    Citation: Genes and Environment 2019 41:12
    Content type: Correction Published on:

    The original article was published in Genes and Environment 2018 40:26

  5. Chloroethylnitrosourea (CENU) derivatives, such as nimustine (ACNU) and carmustine (BCNU), are employed in brain tumor chemotherapy due to their ability to cross the blood-brain barrier. They are thought to su...

    Authors: Yoko Yamada, Shinji Watanabe, Keinosuke Okamoto, Sakae Arimoto, Eizo Takahashi, Kazuo Negishi and Tomoe Negishi
    Citation: Genes and Environment 2019 41:11
    Content type: Research Published on:

  9. The harmful effects of fine particles with an aerodynamic diameter less than 2.5 μm (PM2.5) on respiratory organs are emphasized in pollution studies because PM2.5 have high deposition rates in the respiratory...

    Authors: Kazutoshi Sugita, Yuka Kin, Mayuko Yagishita, Fumikazu Ikemori, Kimiyo Kumagai, Toshihiko Ohara, Makoto Kinoshita, Kazuyuki Nishimura, Yukihiko Takagi and Daisuke Nakajima
    Citation: Genes and Environment 2019 41:7
    Content type: Research Published on:

  10. The Pig-a assay, a promising tool for evaluating in vivo genotoxicity, is based on flow cytometric enumeration of red blood cells (RBCs) that are deficient in glycosylphosphatidylinositol anchor protein. Various ...

    Authors: Satsuki Chikura, Takafumi Kimoto, Satoru Itoh, Hisakazu Sanada, Shigeharu Muto and Katsuyoshi Horibata
    Citation: Genes and Environment 2019 41:5
    Content type: Method Published on:

  11. The in vitro micronucleus (MN) test is an important component of a genotoxicity test battery that evaluates chemicals. Although the standard method of manually scoring micronucleated (MNed) cells by microscope...

    Authors: Akira Takeiri, Kaori Matsuzaki, Shigeki Motoyama, Mariko Yano, Asako Harada, Chiaki Katoh, Kenji Tanaka and Masayuki Mishima
    Citation: Genes and Environment 2019 41:4
    Content type: Research Published on:

  13. Nucleotide excision repair (NER) is a versatile DNA repair pathway, which can remove an extremely broad range of base lesions from the genome. In mammalian global genomic NER, the XPC protein complex initiates...

    Authors: Masayuki Kusakabe, Yuki Onishi, Haruto Tada, Fumika Kurihara, Kanako Kusao, Mari Furukawa, Shigenori Iwai, Masayuki Yokoi, Wataru Sakai and Kaoru Sugasawa
    Citation: Genes and Environment 2019 41:2
    Content type: Review Published on:

  14. Evidence from epidemiological and experimental studies has shown that the etiology of colorectal cancer (CRC) is related to lifestyle, mainly diet. At the same time, there are many foods and beverages that hav...

    Authors: Shuya Tamura, Takumi Narita, Gen Fujii, Shingo Miyamoto, Takahiro Hamoya, Yurie Kurokawa, Maiko Takahashi, Kouhei Miki, Yui Matsuzawa, Masami Komiya, Masaru Terasaki, Tomohiro Yano and Michihiro Mutoh
    Citation: Genes and Environment 2019 41:1
    Content type: Research Published on:

  16. The US National Academy of Sciences (NAS) presented the linear no-threshold hypothesis (LNT) in 1956, which indicates that the lowest doses of ionizing radiation are hazardous in proportion to the dose. This s...

    Authors: Shizuyo Sutou
    Citation: Genes and Environment 2018 40:26
    Content type: Commentary Published on:

    The Correction to this article has been published in Genes and Environment 2019 41:12

  17. Previously we found that DNA adducts were accumulated in the lungs of the rats exposed to ambient air in the Tokyo metropolitan area. To examine chronological change in in vivo mutagenicity of airborne particl...

    Authors: Yasunobu Aoki, Daisuke Nakajima, Michiyo Matsumoto, Mayuko Yagishita, Michi Matsumoto, Rie Yanagisawa, Sumio Goto, Kenichi Masumura and Takehiko Nohmi
    Citation: Genes and Environment 2018 40:25
    Content type: Research Published on:

  18. A wide variety of DNA lesions interfere with replication and transcription, leading to mutations and cell death. DNA repair mechanisms act upon these DNA lesions present in the genomic DNA. To investigate a DN...

    Authors: Mika Yukutake, Mika Hayashida, Narumi Shioi Aoki and Isao Kuraoka
    Citation: Genes and Environment 2018 40:23
    Content type: Research Published on:

  19. The Open Symposium of the Japanese Environmental Mutagen Society (JEMS) entitled “Challenges of Young Scientists at the Cutting-edge of Genotoxicity Research” was held in the Main Conference Room of the Founda...

    Authors: Manabu Yasui, Shigeharu Muto and Akira Sassa
    Citation: Genes and Environment 2018 40:22
    Content type: Meeting report Published on:

  22. According to the linear no-threshold model (LNT), even the smallest amount of radiation is hazardous. Although the LNT is not based on solid data, this hypothesis has been applied to mutagens and carcinogens. ...

    Authors: Shizuyo Sutou, Akiko Koeda, Kana Komatsu, Toshiyuki Shiragiku, Hiroshi Seki, Kohji Yamakage, Takeru Niitsuma, Toshiyuki Kudo and Akihiro Wakata
    Citation: Genes and Environment 2018 40:20
    Content type: Research Published on:

  23. Use of Quantitative Structure-Activity Relationships ((Q)SAR) prediction tools has been increasing since the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use ...

    Authors: Masayuki Mishima, Tsuneo Hashizume, Yu Haranosono, Yusuke Nagato, Kentaro Takeshita, Junichi Fukuchi and Masamitsu Homma
    Citation: Genes and Environment 2018 40:19
    Content type: Meeting report Published on:

  25. The carcinogenic potential of dimethylaniline (DMA) isomers in rodents and humans has been previously reported, and there is sufficient evidence for the carcinogenicity of 2,6-DMA in experimental animals. The ...

    Authors: Arihiro Kohara, Mariko Matsumoto, Akihiko Hirose, Makoto Hayashi, Masamitsu Honma and Takayoshi Suzuki
    Citation: Genes and Environment 2018 40:18
    Content type: Research Published on:

  26. Grx6 is a yeast Golgi/endoplasmic reticulum protein involved in iron-sulfur binding that belongs to monothiol glutaredoxin-protein family. Grx6 has been biochemically characterized previously. Grx6 contains a ...

    Authors: Mohnad Abdalla, Wafa Ali Eltayb, Amr Ahmed El-Arabey, Raihan Mo, T. I. M. Dafaalla, Hamed I. Hamouda, Eijaz Ahmed Bhat, Annoor Awadasseid and Hassan Abdellha Ahmed Ali
    Citation: Genes and Environment 2018 40:15
    Content type: Research Published on:

  27. Nucleoside triphosphates participate in fundamental cellular processes as building blocks of DNA and RNA, energy carriers, and cofactors in enzymatic reactions, and their balance is tightly regulated. Here, we...

    Authors: Shun Matsuda and Toshihiko Kasahara
    Citation: Genes and Environment 2018 40:13
    Content type: Research Published on:

  30. There is still considerable debate about the effects of exposure to bisphenol A (BPA) an endocrine disrupter at low doses. Recently, many studies using animal models have shown that prenatal BPA exposure induc...

    Authors: Toshiki Aiba, Toshiyuki Saito, Akiko Hayashi, Shinji Sato, Harunobu Yunokawa, Toru Maruyama, Wataru Fujibuchi and Seiichiroh Ohsako
    Citation: Genes and Environment 2018 40:12
    Content type: Research Published on:

  32. ÎłH2AX, the phosphorylated form of a histone variant H2AX at Ser 139, is already widely used as a biomarker to research the fundamental biology of DNA damage and repair and to assess the risk of environmental c...

    Authors: Shigeki Motoyama, Akira Takeiri, Kenji Tanaka, Asako Harada, Kaori Matsuzaki, Junko Taketo, Saori Matsuo, Etsuko Fujii and Masayuki Mishima
    Citation: Genes and Environment 2018 40:10
    Content type: Review Published on:

  33. The International Association of Environmental Mutagenesis and Genomics Societies (IAEMGS) is a global organization that promotes applied and basic research on environmental mutagenesis and genomics. IAEMGS is...

    Authors: Takehiko Nohmi, Catarina S. Takahashi, Byung-Mu Lee, Michael F. Fenech and Masami Yamada
    Citation: Genes and Environment 2018 40:9
    Content type: Meeting report Published on:

  34. A large-scale study was conducted by multiple laboratories affiliated with the Japanese Environmental Mutagen Society and the Bacterial Mutagenicity Study Group to investigate possible proficiency indicators f...

    Authors: Masayuki Kato, Kei-ichi Sugiyama, Toshiro Fukushima, Yasuyoshi Miura, Takumi Awogi, Shigetomo Hikosaka, Kumiko Kawakami, Madoka Nakajima, Masato Nakamura, Hajime Sui, Kumiko Watanabe and Atsushi Hakura
    Citation: Genes and Environment 2018 40:7
    Content type: Short report Published on:

  35. Oxidative stress leads to many kinds of diseases. Currently, urinary 8-hydroxydeoxyguanosine (8-OHdG) is widely measured as an oxidative stress biomarker. There is a specific advantage if saliva can be used as...

    Authors: Kazuaki Kawai, Hiroshi Kasai, Yun-Shan Li, Yuya Kawasaki, Shintaro Watanabe, Masanori Ohta, Toru Honda and Hiroshi Yamato
    Citation: Genes and Environment 2018 40:5
    Content type: Short report Published on:

  36. We examined the correlation between the results of in vitro and in vivo chromosomal damage tests by using in-house data of 18 pharmaceutical candidates that showed positive results in the in vitro chromosomal ...

    Authors: Eiji Yamamura, Chinami Aruga, Shigeharu Muto, Nobuyuki Baba and Yoshifumi Uno
    Citation: Genes and Environment 2018 40:6
    Content type: Short report Published on:

  38. The in vivo comet assay is a widely used genotoxicity test that can detect DNA damage in a range of organs. It is included in the Organisation for Economic Co-operation and Development Guidelines for the Testi...

    Authors: Takahiro Kyoya, Rika Iwamoto, Yuko Shimanura, Megumi Terada and Shuichi Masuda
    Citation: Genes and Environment 2018 40:4
    Content type: Short report Published on:

  39. Oxidative damage is an important genotoxic source for almost all organisms. To efficiently detect mutations induced by oxidative damage, we previously developed a urate-null Drosophila strain. Using this Droso...

    Authors: Ryota Koike, Tomoyo Uchiyama, Sakae Arimoto-Kobayashi, Keinosuke Okamoto and Tomoe Negishi
    Citation: Genes and Environment 2018 40:3
    Content type: Research Published on:

  40. We have demonstrated that retrospective evaluation of existing data of in vitro chromosomal aberration test using the new cytotoxicity indices RICC (relative increase in cell count) or RPD (relative population...

    Authors: Hiroshi Honda, Yurika Fujita, Toshio Kasamatsu, Anne Fuchs, Rolf Fautz and Osamu Morita
    Citation: Genes and Environment 2018 40:2
    Content type: Letter to the Editor Published on:

  41. Environmental factors stimulate alteration of DNA methylation level. Investigation of the genome-wide DNA methylation status is important for environmental health studies. We here designed a genomic DNA amplif...

    Authors: Hisaka Kurita, Toshiki Aiba, Toshiyuki Saito and Seiichiroh Ohsako
    Citation: Genes and Environment 2018 40:1
    Content type: Short report Published on:

  42. The high-fidelity transmission of genetic information is crucial for the survival of organisms, the cells of which have the ability to protect DNA against endogenous and environmental agents, including reactiv...

    Authors: Sayoko Ito-Harashima and Takashi Yagi
    Citation: Genes and Environment 2017 39:28
    Content type: Review Published on:

  43. Apurinic/apyrimidinic (AP) sites are one of the most frequent DNA lesions. AP sites inhibit transcription and DNA replication, and induce cell death. AP endonucleases are key enzymes in AP site repair. Several...

    Authors: Masafumi Funakoshi, Daisuke Nambara, Yuichiro Hayashi and Qiu-Mei Zhang-Akiyama
    Citation: Genes and Environment 2017 39:27
    Content type: Short report Published on:

  44. The open symposium of the Japanese Environmental Mutagen Society (JEMS) titled, “Research on Environmental Mutagenesis from Young Scientists,” was held at Kokusai Kenkyu Koryu Kaikan, the Foundation for Promot...

    Authors: Kenichi Masumura and Shuichi Masuda
    Citation: Genes and Environment 2017 39:26
    Content type: Meeting report Published on:

  45. The adverse effects of Asian dust (AD) on health have been demonstrated in earlier studies, but there is no standardized definition for heavy–AD. This study aimed to examine which definition of heavy–AD has th...

    Authors: Jun Kurai, Masanari Watanabe, Hisashi Noma, Kyoko Iwata, Jumpei Taniguchi, Hiroyuki Sano, Yuji Tohda and Eiji Shimizu
    Citation: Genes and Environment 2017 39:25
    Content type: Research Published on:

  46. The commonly consumed antioxidants β-carotene and tea polyphenols were used to assess their protective effects against γ-radiation induced sex-linked recessive lethal (SLRL) mutation and oxidative stress in Droso...

    Authors: Isha Nagpal and Suresh K. Abraham
    Citation: Genes and Environment 2017 39:24
    Content type: Research Published on:

  48. Blackcurrant (Ribs nigrum L.) is a classical fruit that has long been used to prepare juice, jam, liqueur, and sometimes medicines in Europe. Previously, we reported a genome defense effect by the antioxidative a...

    Authors: Ayumi Yamamoto, Tokuhisa Hirouchi, Saori Kawamorita, Kana Nakashima, Atena Sugiyama and Yoji Kato
    Citation: Genes and Environment 2017 39:22
    Content type: Short report Published on:

  49. Guanine is the most readily oxidized of the four DNA bases, and guanine oxidation products cause G:C-T:A and G:C-C:G transversions through DNA replication. 8-Oxo-7,8-dihydroguanine (8-oxoG) causes G:C-T:A tran...

    Authors: Katsuhito Kino, Masayo Hirao-Suzuki, Masayuki Morikawa, Akane Sakaga and Hiroshi Miyazawa
    Citation: Genes and Environment 2017 39:21
    Content type: Review Published on:

  50. Genetic and environmental risk factors play an important role for the susceptibility to sporadic Parkinson’s disease (PD). It was hypothesized that a splice variant of the CYP2D6 gene (CYP2D6*4 allele) is associa...

    Authors: Anwarullah, Muhammad Aslam, Mazhar Badshah, Rashda Abbasi, Aneesa Sultan, Kafaitullah Khan, Nafees Ahmad and Jakob von Engelhardt
    Citation: Genes and Environment 2017 39:18
    Content type: Research Published on:

Genes and Environment is an official journal of The Japanese Environmental Mutagen and Genome Society (JEMS).

JEMS logo
Submit manuscript

Annual Journal Metrics

  • Citation Impact 2023
    Journal Impact Factor: 2.7
    5-year Journal Impact Factor: 2.3
    Source Normalized Impact per Paper (SNIP): 0.798
    SCImago Journal Rank (SJR): 0.593

    Speed 2024
    Submission to first editorial decision (median days): 7
    Submission to acceptance (median days): 105

    Usage 2024
    Downloads: 199,510
    Altmetric mentions: 53

Follow

Genes and Environment

ISSN: 1880-7062

Contact us