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  1. The 47th Annual Conference and the Golden Jubilee Year Meeting of the Environmental Mutagen Society of India (EMSI) and International Conference on Environmental and Molecular Mutagenesis: Genomic Integrity an...

    Authors: Bani Bandana Ganguly
    Citation: Genes and Environment 2025 47:9
    Content type: Meeting Report Published on:

  3. Bleomycin (Bleo) is a glycopeptide with potent antitumor activity that induces DNA double-strand breaks (DSBs) through free radical generation, similar to ionizing radiation (IR). Therefore, Bleo is considered...

    Authors: Naoto Shimizu, Kazuki Izawa, Mubasshir Washif, Ryosuke Morozumi, Kouji Hirota and Masataka Tsuda
    Citation: Genes and Environment 2025 47:7
    Content type: Research Published on:

  4. The symposium “The New Era Shaped by Environmental Genome Monitoring,” held in December 2024 by the Japanese Environmental Mutagen and Genome Society (JEMS), aimed to explore the interdisciplinary collaboratio...

    Authors: Hiroshi Honda, Takayoshi Suzuki, Masaaki Kitajima, Natsuko Ito Kondo, Kaede Miyata, Shunsuke Utsumi and Masami Yamada
    Citation: Genes and Environment 2025 47:6
    Content type: Meeting Report Published on:

  6. Almost 70 years have passed since the molecular mechanism of carcinogenesis was hypothesized to involve multiple gene mutations. More than 1,000 cancer-related genes, including oncogenes and tumor suppressor g...

    Authors: HeeKyung Seong, Runa Izutsu, Mitsuhiko Osaki and Futoshi Okada
    Citation: Genes and Environment 2025 47:4
    Content type: Review Published on:

  8. Skin is exposed to various environmental factors throughout life, and some of these factors are known to contribute to skin aging. Long-term solar UV exposure is a well-known cause of skin aging, as is cigaret...

    Authors: Ryoma Ito, Yukako Komaki and Yuko Ibuki
    Citation: Genes and Environment 2025 47:2
    Content type: Research Published on:

  9. Urinary 8-hydroxyguanosine (8-OHGuo) levels serve as a biomarker for oxidative stress and hydroxyl radical–induced RNA damage. Evaluating the diurnal and daily fluctuations in urinary 8-OHGuo excretion levels ...

    Authors: Yun-Shan Li, Koichi Fujisawa and Kazuaki Kawai
    Citation: Genes and Environment 2025 47:1
    Content type: Research Published on:

  10. Previously, Japanese Environmental Mutagen and Genome Society/Mammalian Mutagenicity Study Group/Toxicogenomics Study Group (JEMS/MMS toxicogenomic study group) proposed 12 genotoxic marker genes (Aen, Bax, Btg2,...

    Authors: Chie Furihata and Takayoshi Suzuki
    Citation: Genes and Environment 2024 46:28
    Content type: Research Published on:

  11. Lung adenocarcinoma (LUAD) is the most common histological type of non-small cell lung cancer (NSCLC). Platinum-based chemotherapy, such as cisplatin chemotherapy, is the cornerstone of treatment for LUAD pati...

    Authors: Xingxing Shao, Hailang Hou, Huijie Chen, Wan Xia, Xinpu Geng and Jindao Wang
    Citation: Genes and Environment 2024 46:27
    Content type: Research Published on:

  12. When assessing the genotoxicity of substances containing probiotic candidates, such as lactic acid-producing bacteria, using the in vitro micronucleus test (MNT), bacterial growth in the test medium may reduce...

    Authors: Yohei Fujiishi, Wakako Ohyama and Emiko Okada
    Citation: Genes and Environment 2024 46:26
    Content type: Research Published on:

  13. The rose ketone β-damascone (β-Dam) elicits positive results in the in vitro micronucleus (MN) assay using human lymphocytes, but shows negative outcomes in the Ames test and combined in vivo MN and comet assa...

    Authors: Tsuneo Hashizume, Satoru Munakata, Tomohiro Takahashi and Taku Watanabe
    Citation: Genes and Environment 2024 46:25
    Content type: Research Published on:

  14. Primary aromatic amines (PAAs) present significant challenges in the prediction of mutagenicity using current standard quantitative structure activity relationship (QSAR) systems, which are knowledge-based and...

    Authors: Shigeharu Muto, Ayako Furuhama, Mika Yamamoto, Yasuteru Otagiri, Naoki Koyama, Seiji Hitaoka, Yusuke Nagato, Hirofumi Ouchi, Masahiro Ogawa, Kisako Shikano, Katsuya Yamada, Satoshi Ono, Minami Hoki, Fumiya Ishizuka, Soichiro Hagio, Chiaki Takeshita…
    Citation: Genes and Environment 2024 46:24
    Content type: Research Published on:

  15. Although the in silico predictive ability of the Ames test results has recently made remarkable progress, there are still some chemical classes for which the predictive ability is not yet sufficient due to a l...

    Authors: Masaki Kurakami, Atsushi Hakura, Rika Sato, Akihiro Kawade, Takeshi Yamagata, Naoki Koyama, Dai Kakiuchi and Shoji Asakura
    Citation: Genes and Environment 2024 46:23
    Content type: Research Published on:

  16. We previously investigated methods for separating mutagenic contaminants from aqueous solutions using cellulose-bearing covalently bound trisulfo-Cu-phthalocyanine (blue cotton and blue rayon). Mutagenic conta...

    Authors: Kayoko Sano, Yuka Soga, Kaori Ohta, Yuki Kitamura and Sakae Arimoto-Kobayashi
    Citation: Genes and Environment 2024 46:22
    Content type: Research Published on:

  17. Both mutation induction and clonal expansion of mutated cells cause cancer. The probability of cancer development depends on mutations, clonal growth rates, and carcinogenic mechanisms. A recent study showed c...

    Authors: Masahiko Watanabe, Hiroshi Haeno, Sachiyo Mimaki and Katsuya Tsuchihara
    Citation: Genes and Environment 2024 46:21
    Content type: Research Published on:

  18. Error-corrected next-generation sequencing (ecNGS) technologies have enabled the direct evaluation of genome-wide mutations after exposure to mutagens. Previously, we reported an ecNGS methodology, Hawk-Seq™, ...

    Authors: Sayaka Hosoi, Takako Hirose, Shoji Matsumura, Yuki Otsubo, Kazutoshi Saito, Masaaki Miyazawa, Takayoshi Suzuki, Kenichi Masumura and Kei-ichi Sugiyama
    Citation: Genes and Environment 2024 46:20
    Content type: Short report Published on:

  20. Poly(ADP-ribose) polymerase-1 (PARP-1) is a pan nuclear protein that utilizes NAD+ as a substrate for poly(ADP-ribosyl)ation reaction (PARylation), resulting in both auto-modification and the modification of its ...

    Authors: Atanu Ghorai, Soumajit Saha and Basuthkar J. Rao
    Citation: Genes and Environment 2024 46:18
    Content type: Short report Published on:

  21. Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer commonly used in a wide variety of products, including medical devices. It is rapidly metabolized in the liver into various metabolites upon absorption throug...

    Authors: Miyuki Shigano, Rie Takashima, Kensuke Satomoto, Henri Sales, Ryoko Harada and Shuichi Hamada
    Citation: Genes and Environment 2024 46:17
    Content type: Short report Published on:

  23. Exposure to chemical mixtures inherent in air pollution, has been shown to be associated with the risk of breast and lung cancers. However, studies on the molecular mechanisms of exposure to a mixture of these...

    Authors: A’edah Abu-Bakar, Maihani Ismail, M. Zaqrul Ieman Zulkifli, Nur Aini Sofiyya Zaini, Nur Izzah Abd Shukor, Sarahani Harun and Salmaan Hussain Inayat-Hussain
    Citation: Genes and Environment 2024 46:15
    Content type: Research Published on:

  24. Long non-coding RNA (lncRNA) is a group of RNA transcripts that contribute to tumor development by post-transcriptionally regulating cancer-related genes. Nasopharyngeal carcinoma (NPC) is an epithelial tumor ...

    Authors: Huan Wang, Fuming Zhou, Jia Wan, Hong Yu and Jin Wang
    Citation: Genes and Environment 2024 46:14
    Content type: Research Published on:

  25. Rosmarinic acid (RA) has a wide range of beneficial effects on human health. On the other hand, RA has been reported to induce metal-mediated reactive oxygen species (ROS) generation and DNA damage. However, i...

    Authors: Hatasu Kobayashi, Yuichiro Hirao, Shosuke Kawanishi, Shinya Kato, Yurie Mori, Mariko Murata and Shinji Oikawa
    Citation: Genes and Environment 2024 46:13
    Content type: Research Published on:

  26. Sinonasal adenocarcinoma is a rare cancer, encompassing two different entities, the intestinal-type sinonasal adenocarcinoma (ITAC) and the non-intestinal-type sinonasal adenocarcinoma (non-ITAC). Occurrence o...

    Authors: Lauri J. Sipilä, Riku Katainen, Mervi Aavikko, Janne Ravantti, Iikki Donner, Rainer Lehtonen, Ilmo Leivo, Henrik Wolff, Reetta Holmila, Kirsti Husgafvel-Pursiainen and Lauri A. Aaltonen
    Citation: Genes and Environment 2024 46:12
    Content type: Research Published on:

  27. An in vitro micronucleus assay is a standard genotoxicity test. Although the technique and interpretation of the results are simple, manual counting of the total and micronucleus-containing cells in a microsco...

    Authors: Hiromi Yoda, Kazuya Abe, Hideya Takeo, Takeji Takamura-Enya and Ayumi Koike-Takeshita
    Citation: Genes and Environment 2024 46:11
    Content type: Research Published on:

  28. As a natural extraction, astaxanthin is gaining increasing attention because of its safety and anti-tumor properties. It has been reported to participate in the progression of various types of cancer such as g...

    Authors: Yajia Xu and Chengyi Jiang
    Citation: Genes and Environment 2024 46:10
    Content type: Research Published on:

  29. Authors: Augustin Nzitakera, Jean Bosco Surwumwe, Ella Larissa Ndoricyimpaye, Schifra Uwamungu, Delphine Uwamariya, Felix Manirakiza, Marie Claire Ndayisaba, Gervais Ntakirutimana, Benoit Seminega, Vincent Dusabejambo, Eric Rutaganda, Placide Kamali, François Ngabonziza, Rei Ishikawa, Belson Rugwizangoga, Yuji Iwashita…
    Citation: Genes and Environment 2024 46:9
    Content type: Correction Published on:

    The original article was published in Genes and Environment 2024 46:8

  30. Gastric cancer is the sixth most frequently diagnosed cancer and third in causing cancer-related death globally. The most frequently mutated gene in human cancers is TP53, which plays a pivotal role in cancer ini...

    Authors: Augustin Nzitakera, Jean Bosco Surwumwe, Ella Larissa Ndoricyimpaye, Schifra Uwamungu, Delphine Uwamariya, Felix Manirakiza, Marie Claire Ndayisaba, Gervais Ntakirutimana, Benoit Seminega, Vincent Dusabejambo, Eric Rutaganda, Placide Kamali, François Ngabonziza, Rei Ishikawa, Belson Rugwizangoga, Yuji Iwashita…
    Citation: Genes and Environment 2024 46:8
    Content type: Research Published on:

    The Correction to this article has been published in Genes and Environment 2024 46:9

  31. Carbendazim (methyl 2-benzimidazolecarbamate, CASRN: 10605-21-7) exhibits spindle poisoning effects and is widely used as a fungicide. With respect to genotoxicity, carbendazim is deemed to be non-mutagenic in...

    Authors: Takako Iso, Kenichiro Suzuki, Yasumasa Murata, Nozomu Hirose, Takaaki Umano, Katsuyoshi Horibata, Kei-ichi Sugiyama, Akihiko Hirose, Kenichi Masumura and Mariko Matsumoto
    Citation: Genes and Environment 2024 46:7
    Content type: Short report Published on:

  34. Previously, we have reported on the two curcuminoid analogues with piperidone derivatives, namely FLDP-5 and FLDP-8 have more potent anti-proliferative and anti-migration effects than curcumin. In this study, ...

    Authors: Nur Syahirah Che Razali, Kok Wai Lam, Nor Fadilah Rajab, A. Rahman A. Jamal, Nurul Farahana Kamaludin and Kok Meng Chan
    Citation: Genes and Environment 2024 46:4
    Content type: Research Published on:

  35. A micronucleus test is generally used to evaluate the genotoxic potential of chemicals. Exaggerated erythropoiesis, as occurs following bleeding, may induce an unexpected increase in micronucleus frequency. Th...

    Authors: Yuki Okada, Satsuki Chikura, Takafumi Kimoto and Takeshi Iijima
    Citation: Genes and Environment 2024 46:3
    Content type: Research Published on:

  36. Non-SMC condensin I complex subunit D2 (NCAPD2) belongs to the chromosomal structural maintenance family. While the different contribution of NCAPD2 to chromosome in mitosis have been thoroughly investigated, ...

    Authors: Linyuan Feng, Yang Yang, Zhenhua Lin, Minghua Cui, Aihua Jin and Aili Cui
    Citation: Genes and Environment 2024 46:2
    Content type: Research Published on:

    The Correction to this article has been published in Genes and Environment 2024 46:6

  37. Gastric cancer (GC) is a common malignancy with its morbidity increasing worldwide. Hence, it is imperative to develop effective treatments. Studies have shown that metformin has potential antitumor effects. T...

    Authors: Rui Chen, Jianhui Chen, Miaoliang Chen, Shenkang Zhou and Pinlu Jiang
    Citation: Genes and Environment 2024 46:1
    Content type: Research Published on:

  38. Selenium (Se) is an essential micronutrient for humans, but its deficiency as well as toxicity affects large number of people worldwide. Plantago ovata, a commercially important medicinal plant, is mainly cultiva...

    Authors: Sankalan Dey and Sarmistha Sen Raychaudhuri
    Citation: Genes and Environment 2023 45:38
    Content type: Research Published on:

  39. DNA damage response (DDR) and repair are vital for safeguarding genetic information and ensuring the survival and accurate transmission of genetic material. DNA damage, such as DNA double-strand breaks (DSBs),...

    Authors: Shun Matsuda, Tsuyoshi Ikura and Tomonari Matsuda
    Citation: Genes and Environment 2023 45:37
    Content type: Short report Published on:

  41. The number of breast cancer patients is increasing worldwide. Furthermore, breast cancer often develops in young people, even those only in their 30s, who play a central role in their families and society. Res...

    Authors: Takahiro Tsukioki, Seema A. Khan and Tadahiko Shien
    Citation: Genes and Environment 2023 45:35
    Content type: Review Published on:

  42. The Malaysian Society of Toxicology (MySOT), founded in 2010, emerged as a response to the growing need for a collective and interdisciplinary effort to study the effects of substances on human health, and the...

    Authors: Nurul Farahana Kamaludin, Firdaus Kamarulzaman, Rozaini Abdullah, Kok Meng Chan and Salmaan Hussain Inayat-Hussain
    Citation: Genes and Environment 2023 45:34
    Content type: Letter to the Editor Published on:

  43. Carcinogenic risk assessment studies have been repeatedly improved and are still being debated to find a goal. Evaluation might be changed if new approaches would be applied to some chemicals which means that ...

    Authors: Masami Yamada, Takayoshi Suzuki, Arihiro Kohara and Masamitsu Honma
    Citation: Genes and Environment 2023 45:33
    Content type: Short report Published on:

  44. Non-Small Cell Lung Cancer displays several genetic mutations including epidermal growth factor receptor. This study's objective was to determine if the EGFR exon19 rs121913438 and exon21 rs121434568 variation...

    Authors: Omali Y. El-khawaga, Mohammed F. Al-azzawy, Afaf M. ElSaid, Sherif Refaat and Aliaa N. El-Dawa
    Citation: Genes and Environment 2023 45:32
    Content type: Research Published on:

  45. Aflatoxin B1 (AFB1) is a mycotoxin produced by several species of Aspergillus fungi which can cause liver cancer in animals and humans. This study aims to perform the risk assessment of AFB1 in herbal medicines a...

    Authors: Siti Soleha Ab Dullah, Mohd Redzwan Sabran, Ab Hamid Hasiah and Rozaini Abdullah
    Citation: Genes and Environment 2023 45:31
    Content type: Research Published on:

  46. Mutagenicity, the ability of chemical agents to cause mutations and potentially lead to cancer, is a critical aspect of substance safety assessment for protecting human health and the environment. Metabolic en...

    Authors: Kazuki Izawa, Masataka Tsuda, Takayoshi Suzuki, Masamitsu Honma and Kei-ichi Sugiyama
    Citation: Genes and Environment 2023 45:30
    Content type: Short report Published on:

  47. tert-Butyl hydroperoxide (TBHP; CAS 75–91-2), a hydroperoxide, is mainly used as a polymerization initiator to produce polyethylene, polyvinyl chloride, and unsaturated polyester. It is a high-production chemical...

    Authors: Yasumasa Murata, Kenichiro Suzuki, Yoshiyuki Shigeta, Takako Iso, Nozomu Hirose, Takaaki Umano, Katsuyoshi Horibata, Kei-ichi Sugiyama, Akihiko Hirose, Kenichi Masumura and Mariko Matsumoto
    Citation: Genes and Environment 2023 45:29
    Content type: Short report Published on:

  48. The species of genus Macaranga are widely found in Malaysian secondary forests and has been used as an alternative for treating varieties of illness. Studies have shown that the medicinal properties of this genus...

    Authors: Ee Ling Siew, Lishantini Pearanpan, Zhafri Zamkhuri, Fariza Juliana Nordin, Theng Choon Ooi, Kok Meng Chan, Aisyah Salihah Kamarozaman, Norizan Ahmat and Nor Fadilah Rajab
    Citation: Genes and Environment 2023 45:28
    Content type: Research Published on:

  49. The DNA-damaging compounds in heated cooking oil were identified as guanosine adducts. Heated vegetable oil was subjected to deep-frying conditions at 170 Â°C for 45 min, reacted with isopropylidene guanosine (...

    Authors: Hiroshi Kasai and Kazuaki Kawai
    Citation: Genes and Environment 2023 45:27
    Content type: Research Published on:

  50. The aim of this study was to assess the correlation of spouse selection with short tandem repeats (STRs) in DNA and with the number of fingertip lunulae to investigate the role of heredity in spouse selection.

    Authors: Qi Xia, Ullah Anwar, Yu Weijian, Wang Yingshuai and Liu Hui
    Citation: Genes and Environment 2023 45:26
    Content type: Research Published on:

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